We illustrate the convergence of genetics and ophthalmology with sophisticated design and heavy reliance on typography. One widely known way of depicting genetic sequencing (ATCG) Is introduced on the cover. These four letters happen to appear (just one time each) in the title “Applied Genetics.” So the cover highlights them (in bright colors) where they appear in the words. This sequencing reference runs throughout the center of the book as the base element of the design, as it did in the first book. The airy, Swiss-style layout lightens the dense science, breaking it into easily digestible chunks of information, demarcating captions, introductions, and scientific passages. We used large-image, divider-pages spreads to break up the sections and add graphic interest—giving a rhythm to the books narrative. The use of diagrams, infographics and beautiful photomicrographs adds further visual impact. The department is celebrating its 150th anniversary, so we begin with a timeline across four spreads, showing the department’s impressive history of innovation.